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Treatment of E. Coli Urinary Tract Infections
In the given case study, the patient has pyelonephritis and a recurring UTI post hemi-arthroplasty. He has been prescribed Ceftriaxone for the same. Ceftriaxone is a broad-spectrum cephalosporin antibiotic and is administered intravenously or intramuscularly. It is indicated for urinary tract infections, more specifically caused by E.Coli, Proteus vulgaris amongst others. It acts by causing the inhibition of the synthesis of mucopeptide in the cell wall of the bacteria. The beta-lactam part of ceftriaxome binds with the enzymes present in the cytoplasm of the bacterial membrane and cause reduction in enzyme activity, which leads to a production of defective cell walls and eventual cell death.
A retrospective observational study on the usage of Ceftriaxone for the treatment of complicated urinary tract infection showed that – even though, Ceftriaxone did not show much effect on the length of stay in the bed, it was still most effective in the treatment of complicated UTI (Karlović et al., 2018). Another retrospective study conducted on comparing the effects of Ceftriaxone and Levofloxacin for the treatment of urinary tract infection showed that- for patients who were suffering from UTIs which required hospitalizations, Ceftriaxone seems to be the effective choice of treatment in most of the patients as it showed a reduction in the median length of stay in the hospital(Wang et al., 2018).
Reference for Ceftriaxone Usage in UTI
Karlović, K., Nikolić, J., & Arapović, J. (2018). Ceftriaxone treatment of complicated urinary tract infections as a risk factor for enterococcal re-infection and prolonged hospitalization: A 6-year retrospective study. Bosnian Journal of Basic Medical Sciences, 18(4), 361.
Wang, S. S., Ratliff, P. D., & Judd, W. R. (2018). Retrospective review of ceftriaxone versus levofloxacin for treatment of E. coli urinary tract infections. International Journal of Clinical Pharmacy, 40(1), 143-149.
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